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Similar to drugs that need to cross the blood\u2013brain barrier\u00a0(BBB) and blood\u2013spinal cord barrier to gain access to the central nervous system (CNS), drugs must cross the peripheral nerve barriers (PNBs), formed by the perineurium and blood\u2013nerve barrier to modulate peripheral axons. Despite significant progress made to develop effective strategies to enhance BBB permeability in therapeutic drug design, efforts to enhance drug permeability and retention in peripheral nerves and nerve roots are relatively understudied. Guided by knowledge describing structural, molecular, and functional similarities between restrictive neural barriers in the CNS and peripheral nervous system, it is hypothesized that certain CNS drug delivery strategies are adaptable for peripheral nerve drug delivery. Here, the molecular, structural, and functional similarities and differences between the BBB and PNB are described, existing CNS and peripheral nerve drug delivery strategies are summarized and compared, and the potential application of selected CNS delivery strategies to improve efficacious drug entry for peripheral nerve disorders is discussed.<\/jats:p>","DOI":"10.1002\/adtp.202200150","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T21:34:58Z","timestamp":1674077698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Drug Permeability: From the Blood\u2013Brain Barrier to the Peripheral Nerve Barriers"],"prefix":"10.1002","volume":"6","author":[{"given":"Yifei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering The University of Alabama  Tuscaloosa AL 35487 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Zabihi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering The University of Alabama  Tuscaloosa AL 35487 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering The University of Alabama  Tuscaloosa AL 35487 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering The University of Alabama  Tuscaloosa AL 35487 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The University of Alabama  Tuscaloosa AL 35487 USA"},{"name":"Department of Microbiology Heersink School of Medicine University of Alabama at Birmingham  Birmingham AL 35294 USA"},{"name":"Center for Convergent Biosciences and Medicine University of Alabama  Tuscaloosa AL 35487 USA"},{"name":"Alabama Life Research Institute University of Alabama  Tuscaloosa AL 35487 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eroboghene E.","family":"Ubogu","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Disease Department of Neurology Heersink School of Medicine University of Alabama at Birmingham  Birmingham AL 35294 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa N.","family":"Raja","sequence":"additional","affiliation":[{"name":"Division of Pain Medicine Department of Anesthesiology &amp; 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