{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:27:53Z","timestamp":1778182073249,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771057"],"award-info":[{"award-number":["31771057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91439116"],"award-info":[{"award-number":["91439116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The transplant of small\u2010diameter tissue engineering blood vessels (small\u2010diameter TEBVs) (&lt;6 mm) in vascular replacement therapy often fails because of early onset thrombosis and long\u2010standing chronic inflammation. The specific inflammation state involved in small\u2010diameter TEBVs transplants remains unclear, and whether promoting inflammation resolution would be useful for small\u2010diameter TEBVs therapy need study. The neural protuberant orientation factor 1 (Netrin\u20101) is found present in endothelial cells of natural blood vessels and has anti\u2010inflammatory effects. This work generates netrin\u20101\u2010modified small\u2010diameter TEBVs by using layer\u2010by\u2010layer self\u2010assembly to resolve the inflammation. The results show that netrin\u20101 reprograms macrophages (M\u03a6) to assume an anti\u2010inflammatory phenotype and promotes the infiltration and subsequent efflux of M\u03a6 from inflamed sites over time, which improves the local microenvironment and the function of early homing endothelial progenitor cells (EPCs). Small\u2010diameter TEBVs modified by netrin\u20101 achieve endothelialization after 30 d and retain patency at 14 months. These findings suggest that promoting the resolution of inflammation in time is necessary to induce endothelialization of small\u2010diameter TEBVs and prevent early thrombosis and problems associated with chronic inflammation. Furthermore, this work finds that the M\u03a6\u2010derived exosomes can target and regulate EPCs, which may serve as a useful treatment for other inflammatory diseases.<\/jats:p>","DOI":"10.1002\/advs.201700278","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T12:30:39Z","timestamp":1506601839000},"source":"Crossref","is-referenced-by-count":33,"title":["Netrin\u20101 Promotes Inflammation Resolution to Achieve Endothelialization of Small\u2010Diameter Tissue Engineering Blood Vessels by Improving Endothelial Progenitor Cells Function In Situ"],"prefix":"10.1002","volume":"4","author":[{"given":"Yanzhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingcan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feila","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anatomy National and Regional Engineering Laboratory of Tissue Engineering State and Local Joint Engineering Laboratory for Vascular Implants Key Lab for Biomechanics and Tissue Engineering of Chongqing State Key Laboratory of Trauma, burn and Combined injury Third Military Medical University  Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.03.004"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000153160.82975.86"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000073844.41372.38"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001426"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22716"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228773"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8792"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2567"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1565"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-618025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8321"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.066"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01203"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.034"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150622"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.117622"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv092"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13144"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511011103"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1683"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.06.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.064"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00580.2012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0233-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343660"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.06.017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911465107"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201500122"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.06.017"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201500263"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600058"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166660"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248369"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.244970"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-014-0407-3"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303265"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.949"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600254"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0208"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadvs.201700278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.201700278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:23:33Z","timestamp":1759785813000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.201700278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/advs.201700278"],"URL":"https:\/\/doi.org\/10.1002\/advs.201700278","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]},"article-number":"1700278"}}