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Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non\u2010autofluorescence, high chemical stability, large light\u2010penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide\u2010doped UCNPs as efficient probes for biodetection since 2014. 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