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However, simultaneous investigation of distribution and interrelation of RNA and H<jats:sub>2<\/jats:sub>S in living systems is restricted by lack of functional molecular tools. To address this critical challenge, the development of <jats:bold>TP\u2010MIVC<\/jats:bold> is described as the first paradigm of the probes that can concurrently report ribonucleic acid and hydrogen sulfide with distinct fluorescence signals in the cancer cells, zebrafish, and living animals. The advantageous features of the probe include high stability, low background fluorescence, high sensitivity, and two\u2010photon imaging property. Significantly, regardless of normal mice or tumor mice, tumor tissues exhibit stronger fluorescence intensity than other organs. More interestingly, it is found that <jats:bold>TP\u2010MIVC<\/jats:bold> is capable of distinguishing normal mice and tumor mice by in vivo imaging. 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