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A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.<\/jats:p>","DOI":"10.1002\/advs.201800935","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T18:02:08Z","timestamp":1548698528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions"],"prefix":"10.1002","volume":"6","author":[{"given":"Xenofon","family":"Strakosas","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering University of California Santa Cruz  Santa Cruz CA 95064 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Selberg","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering University of California Santa Cruz  Santa Cruz CA 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