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Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF\u2010Lip@PEG) is developed for clinical applications through Ag\u2013S coordination of four\u2010arm\u2010PEG\u2010SH and Ag<jats:sup>+<\/jats:sup>. Compared to MF\u2010PEG, MF\u2010Lip@PEG exhibits self\u2010healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization\u2010promoting effect. The MF\u2010Lip@PEG also exhibits a strong cytoprotective effect against hypoxia\u2010induced apoptosis through regulation of the Bax\/Bcl\u20102\/caspase\u20103 pathway. In a random skin flap animal model, the MF\u2010Lip@PEG is injectable and convenient to deliver into the skin flap, providing excellent anti\u2010inflammation, anti\u2010infection, and proneovascularization effects and significantly reducing the skin flap necrosis rate. In general, the MF\u2010Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of skin flap regeneration.<\/jats:p>","DOI":"10.1002\/advs.201801555","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T00:11:53Z","timestamp":1542413513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Self\u2010Healing and Injectable Hydrogel for Matching Skin Flap Regeneration"],"prefix":"10.1002","volume":"6","author":[{"given":"Xiyuan","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  639 Zhi Zao Ju Road Shanghai 200011 P. R. 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