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Although microRNA\u201029b (miRNA\u201029b) and microRNA\u2010122 (miRNA\u2010122) have great potential in treating liver fibrosis via regulating profibrotic genes in hepatic stellate cells (HSCs), it is still a challenge to achieve a HSC\u2010targeted and meanwhile noninvasively trackable delivery of miRNAs in vivo. Herein, a pH\u2010sensitive and vitamin A (VA)\u2010conjugated copolymer VA\u2013polyethylene glycol\u2013polyethyleneimine\u2013poly(<jats:italic>N<\/jats:italic>\u2010(<jats:italic>N<\/jats:italic>\u2032,<jats:italic>N<\/jats:italic>\u2032\u2010diisopropylaminoethyl)\u2010<jats:italic>co<\/jats:italic>\u2010benzylamino) aspartamide (T\u2010PBP) is synthesized and assembled into superparamagnetic iron oxide (SPIO)\u2010decorated cationic micelle for miRNA delivery. The T\u2010PBP micelle efficiently transports the miRNA\u201029b and miRNA\u2010122 to HSC in a magnetic resonance imaging\u2010visible manner, resulting in a synergistic antifibrosis effect via downregulating the expression of fibrosis\u2010related genes, including collagen type I alpha 1, \u03b1\u2010smooth muscle actin, and tissue inhibitor of metalloproteinase 1. Consequently, the HSC\u2010targeted combination therapy with miRNA\u201029b and miRNA\u2010122 demonstrates a prominent antifibrotic efficacy in terms of improving liver function and relieving hepatic fibrosis.<\/jats:p>","DOI":"10.1002\/advs.201801809","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T09:35:52Z","timestamp":1547544952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Synergistic MicroRNA Therapy in Liver Fibrotic Rat Using MRI\u2010Visible Nanocarrier Targeting Hepatic Stellate Cells"],"prefix":"10.1002","volume":"6","author":[{"given":"Jun","family":"Wu","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-4532","authenticated-orcid":false,"given":"Jinsheng","family":"Huang","sequence":"additional","affiliation":[{"name":"PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat\u2010sen University  Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichi","family":"Kuang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbiao","family":"Chen","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[{"name":"PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat\u2010sen University  Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-1843","authenticated-orcid":false,"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-9579","authenticated-orcid":false,"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-7777","authenticated-orcid":false,"given":"Du","family":"Cheng","sequence":"additional","affiliation":[{"name":"PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat\u2010sen University  Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-0310","authenticated-orcid":false,"given":"Xintao","family":"Shuai","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"},{"name":"PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat\u2010sen University  Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00047"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88881"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27332"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.06.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24281"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.12.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.997874"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1550055"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.039"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27049"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00529.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130246"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070112"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17550"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.9.2730"},{"key":"e_1_2_7_18_1","first-page":"310","volume":"103","author":"Solis Herruzo J. 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