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However, the understanding of whether the intracellular metabolic pathways could be influenced by material\u2010derived cues remains limited, although it is now well appreciated that material cues modulate cell functions. Here, an overview of how the regulation of different aspect of cell metabolism, including energy homeostasis, oxygen homeostasis, and redox homeostasis could contribute to modulation of cell function is provided. Furthermore, recent evidence demonstrating how material cues, including the release of inherent metabolic factors (e.g., ions, regulatory metabolites, and oxygen), tuning of the biochemical cues (e.g., inherent antioxidant properties, cell adhesivity, and chemical composition of nanomaterials), and changing in biophysical cues (topography and surface stiffness), may impact cell metabolism toward modulated cell behavior are discussed. Based on the resurgence of interest in cell metabolism and metabolic regulation, further development of biomaterials enabling metabolic regulation toward dictating cell function is poised to have substantial implications for regenerative engineering.<\/jats:p>","DOI":"10.1002\/advs.201900819","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T02:25:14Z","timestamp":1564367114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Biomaterial\u2010Based Metabolic Regulation in Regenerative Engineering"],"prefix":"10.1002","volume":"6","author":[{"given":"Chuying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Materials Research Institute The Huck Institutes of the Life Sciences The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Kuzma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Materials Research Institute The Huck Institutes of the Life Sciences The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[{"name":"Academy of Orthopedics Guangdong Province Provincial Key Laboratory of Bone and Joint Degenerative Diseases The Third Affiliated Hospital of Southern Medical University  Guangzhou 510280 China"},{"name":"Department of Cell Biology Key Laboratory of Mental Health of the Ministry of Education School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-828X","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Materials Research Institute The Huck Institutes of the Life Sciences The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004467"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3937"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.12.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10063"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.289140.116"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.05.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091777"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302095"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78470"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.12.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.029"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07316-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2010510"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2014.11.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1985910"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/nips.01409.2002"},{"key":"e_1_2_7_19_1","first-page":"990","volume":"111","author":"Yu\u2010Ru Y. 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