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The significance of H<jats:sub>2<\/jats:sub>S\u2010specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H<jats:sub>2<\/jats:sub>S\u2010triggered\/therapeutic system (SHTS) nanoplatforms for H<jats:sub>2<\/jats:sub>S\u2010activated sensing, imaging, and therapy. Herein, the latest SHTS\u2010based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H<jats:sub>2<\/jats:sub>S as a trigger or exogenous H<jats:sub>2<\/jats:sub>S delivery are also included. A comprehensive understanding of the current status of SHTS\u2010based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS\u2010based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined.<\/jats:p>","DOI":"10.1002\/advs.201901724","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T05:47:46Z","timestamp":1571032066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Smart H<sub>2<\/sub>S\u2010Triggered\/Therapeutic System (SHTS)\u2010Based Nanomedicine"],"prefix":"10.1002","volume":"6","author":[{"given":"Weiyu","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalong","family":"Ni","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary T.","family":"Rosenkrans","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianye","family":"Cao","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-0833","authenticated-orcid":false,"given":"Weibo","family":"Cai","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"},{"name":"Department of Pharmaceutical Sciences University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.09.011"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160912"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.32.040192.000545"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.03.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AN01909A"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja203661j"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja207851s"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104305"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC05646F"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03516J"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705660"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-018-9397-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00073"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.75"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403036"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802309"},{"key":"e_1_2_9_21_1","first-page":"6060","volume":"42","author":"Wu J.","year":"2018","journal-title":"Chem. 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