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However, the role of these structures and their physiological relevance remains unknown. Here, it is reported that a ciliary bulb has extracellular vesicle (EV)\u2010like characteristics. The ciliary extracellular\u2010like vesicle (cELV) has a unique dynamic movement and can be released by mechanical fluid force. To better identify the cELV, differential multidimensional proteomic analyses are performed on the cELV. A database of 172 cELV proteins is generated, and all that examined are confirmed to be in the cELV. Repressing the expression of these proteins in vitro and in vivo inhibits cELV formation. In addition to the randomized heart looping, hydrocephalus, and cystic kidney in fish, compensated heart contractility is observed in both fish and mouse models. Specifically, low circulation of cELV results in hypotension with compensated heart function, left ventricular hypertrophy, cardiac fibrosis, and arrhythmogenic characteristics, which result in a high mortality rate in mice. Furthermore, the overall ejection fraction, stroke volume, and cardiac output are significantly decreased in mice lacking cELV. It is thus proposed that the cELV as a nanocompartment within a primary cilium plays an important role in cardiovascular functions.<\/jats:p>","DOI":"10.1002\/advs.201903140","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T09:46:44Z","timestamp":1592300804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Proteomic Identification Reveals the Role of Ciliary Extracellular\u2010Like Vesicle in Cardiovascular Function"],"prefix":"10.1002","volume":"7","author":[{"given":"Ashraf M.","family":"Mohieldin","sequence":"first","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Chapman University  Irvine CA 92618 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajasekharreddy","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Chapman University  Irvine CA 92618 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