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Afatinib (AFT) plays a key role in preventing non\u2010small cell lung carcinoma (NSCLC) growth and spread. To increase the efficiency of drug loading and NSCLC cell tracking, near infrared\u2010persistent luminescence nanomaterials (NIR PLNs), a silica shell\u2010assisted synthetic route for mono\u2010dispersal, are developed and used in the nanovehicle. After optimizing their physical and chemical properties, the NIR PLNs are able to absorb light energy and emit NIR luminescence for several hours. In this research, NIR PLNs are functionalized for drug\u2010carrying capabilities. Effective accumulation of target drugs, such as AFT, using PLN nanomaterials can lead to unique anticancer therapeutic benefits (AFT\u2010PLN). To minimize side effects and increase drug accumulation, nanomaterials with targeting abilities are used instead of simple drugs to inhibit the growth of tumor cells. Thus, the specific targeting aptamer, MAGE\u2010A3 (MAp) is identified, and the PLN to increase its targeting ability (AFT\u2010PLN@MAp) accordingly modified. The advancement of nanoscale techniques in the field of lung cancer is urgently needed; this research presents a plausible diagnostic strategy and a novel method for therapeutic administration.<\/jats:p>","DOI":"10.1002\/advs.201903741","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T04:39:26Z","timestamp":1584160766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Next\u2010Generation Cancer\u2010Specific Hybrid Theranostic Nanomaterials: MAGE\u2010A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis"],"prefix":"10.1002","volume":"7","author":[{"given":"Ming\u2010Hsien","family":"Chan","sequence":"first","affiliation":[{"name":"Genomics Research Center Academia Sinica  Taipei 115 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Tse","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Taiwan University  Taipei 106 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-991X","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies School of Chemistry Sun Yat\u2010Sen University  Guangzhou Guangdong 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-9052","authenticated-orcid":false,"given":"Ru\u2010Shi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Taiwan University  Taipei 106 Taiwan"},{"name":"Department of Mechanical Engineering Graduate Institute of Manufacturing Technology National Taipei University of Technology  Taipei 106 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9213","authenticated-orcid":false,"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Genomics Research Center Academia Sinica  Taipei 115 Taiwan"},{"name":"Department of Biochemistry College of Medicine Kaohsiung Medical University  Kaohsiung 807 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0081-4"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802994"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800049"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b19172"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07606"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29019-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03936"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2015.09.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b13920"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-016-1396-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MH00442G"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2011.09.001"},{"key":"e_1_2_7_15_1","first-page":"187","volume":"7","author":"Liu T. 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