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However, current medical treatments cannot achieve non\u2010invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)\u2010guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)\u2010based nanocomposite (R\u2010s\u2010ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R\u2010s\u2010ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti\u2010CNV treatment\u2010driven changes in the blood vessels are assessed by real\u2010time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. 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