{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:48:41Z","timestamp":1791002921670,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFC1303100"],"award-info":[{"award-number":["2016YFC1303100"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intraoperative diagnosis of metastatic tumors is of significant importance to the treatment of ovarian cancer. NIR\u2010II fluorescence imaging holds great promise for facile detection of tumor in situ with high sensitivity and resolution. Herein, a kind of NIR\u2010II fluorescent polymer dots (NIR\u2010II Pdots) with high brightness is developed for real\u2010time detection of metastatic ovarian cancer via NIR\u2010II fluorescence imaging. The NIR\u2010II Pdots are constructed via the self\u2010assembly of NIR\u2010II emissive aggregation induced emission luminogens (NIR\u2010II AIEgens) and poly (styrene)\u2010graft\u2010poly(ethylene glycol) in water. Such NIR\u2010II Pdots show very high fluorophore contents of nearly 30% and high quantum yield of 5.4% at emission maximum near 1020\u00a0nm. Further modification of the NIR\u2010II Pdots with targeting peptides yields NIR\u2010II Pdots\u2010GnRH, which can afford enhanced affinity of NIR\u2010II Pdots to ovarian cancer. Upon intravenous injection of the NIR\u2010II Pdots, whole\u2010body organs and vessels, peritoneal and lymphatic metastases of ovarian cancer are clearly visualized by NIR\u2010II fluorescence imaging. Under the guidance of NIR\u2010II fluorescence imaging, the metastatic foci with the diameter down to \u22482\u00a0mm can be facilely eliminated. The results indicate preclinical potential value of the NIR\u2010II Pdots for metastatic ovarian cancer detection.<\/jats:p>","DOI":"10.1002\/advs.202000441","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T09:36:34Z","timestamp":1608802594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Ultrabright NIR\u2010II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection"],"prefix":"10.1002","volume":"8","author":[{"given":"Xiaobo","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School &amp; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases &amp; Obstetrics and Gynecology Hospital of Fudan University Fudan University Shanghai  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congjian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of Shanghai Medical School &amp; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases &amp; Obstetrics and Gynecology Hospital of Fudan University Fudan University Shanghai  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-1979","authenticated-orcid":false,"given":"Fuyou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; State Key Laboratory of Molecular Engineering of Polymers &amp; Institute of Biomedicine Science Fudan University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1469"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06917"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3566"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.212"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2472"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7463"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.294"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00234G"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900321"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2014.166"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507473"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201407420"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0056"},{"key":"e_1_2_7_16_1","first-page":"6387","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.04.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn500299p"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.314"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn301282m"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0038-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201612647"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201001459"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201503067"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905643"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05113-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800766"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910555"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201503396"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903530"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm801911n"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05937"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04363A"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10056-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201805549"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801834"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04305"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.4.322"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666161013111155"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102945"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201707174"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC00441A"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00001H"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b04672"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202000441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202000441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202000441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:53:57Z","timestamp":1759755237000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/advs.202000441"],"URL":"https:\/\/doi.org\/10.1002\/advs.202000441","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]},"assertion":[{"value":"2020-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000441"}}