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In most cases, the embryo is transferred to the uterus after several days of in vitro culture. Although studies have identified the beneficial effects of ET on proper embryo development in the earlier stages, this strategy is compromised by the necessity to transfer early embryos (zygotes) back to the fallopian tube instead of the uterus, which requires a more invasive, laparoscopic procedure, termed zygote intrafallopian transfer (ZIFT). Magnetic micromotors offer the possibility to mitigate such surgical interventions, as they have the potential to transport and deliver cellular cargo such as zygotes through the uterus and fallopian tube noninvasively, actuated by an externally applied rotating magnetic field. This study presents the capture, transport, and release of bovine and murine zygotes using two types of magnetic micropropellers, helix and spiral. Although helices represent an established micromotor architecture, spirals surpass them in terms of motion performance and with their ability to reliably capture and secure the cargo during both motion and transfer between different environments. Herein, this is demonstrated with murine oocytes\/zygotes as the cargo; this is the first step toward the application of noninvasive, magnetic micromotor\u2010assisted ZIFT.<\/jats:p>","DOI":"10.1002\/advs.202000843","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T02:21:42Z","timestamp":1595384502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["A Rotating Spiral Micromotor for Noninvasive Zygote Transfer"],"prefix":"10.1002","volume":"7","author":[{"given":"Lukas","family":"Schwarz","sequence":"first","affiliation":[{"name":"Institute for Integrative Nanosciences Leibniz IFW Dresden  Helmholtzstrasse 20 01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy D.","family":"Karnaushenko","sequence":"additional","affiliation":[{"name":"Institute for Integrative Nanosciences Leibniz IFW Dresden  Helmholtzstrasse 20 01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Hebenstreit","sequence":"additional","affiliation":[{"name":"Institute for Integrative Nanosciences Leibniz IFW Dresden  Helmholtzstrasse 20 01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Naumann","sequence":"additional","affiliation":[{"name":"Transgenic Core Facility Max Planck Institute for Molecular Cell Biology and Genetics  Pfotenhauerstrasse 108 01307 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute for Integrative Nanosciences Leibniz IFW Dresden  Helmholtzstrasse 20 01069 Dresden Germany"},{"name":"Material Systems for Nanoelectronics Technische Universit\u00e4t Chemnitz  Reichenhainer Strasse 70 09126 Chemnitz Germany"},{"name":"Nanophysics Technische Universit\u00e4t Dresden  N\u00f6thnitzer Strasse 61 01187 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6149-3732","authenticated-orcid":false,"given":"Mariana","family":"Medina\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Integrative Nanosciences Leibniz IFW Dresden  Helmholtzstrasse 20 01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06398"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201806696"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06727-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau9650"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NR32798H"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201400256"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/545406a"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja047697z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41928-020-0384-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4569"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b01601"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/aa9b48"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04090"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl900186w"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3079655"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2431454"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.137"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201302544"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-19-0096"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.201700160"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5b04221"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000301518"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0279"},{"key":"e_1_2_7_26_1","first-page":"216","volume":"15","author":"Blumenauer V.","year":"2018","journal-title":"J. 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