{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:11Z","timestamp":1790810891103,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006387","name":"Fondation Leenaards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad\u2010spectrum influenza antivirals to be ready for any possible vaccine shortcomings. Anti\u2010influenza drugs are available but they are far from ideal. Arguably, an ideal antiviral should target conserved viral domains and be virucidal, that is, irreversibly inhibit viral infectivity. Here, a new class of broad\u2010spectrum anti\u2010influenza macromolecules is described that meets these criteria and display exceedingly low toxicity. These compounds are based on a cyclodextrin core modified on its primary face with long hydrophobic linkers terminated either in 6'sialyl\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyllactosamine (6\u2019SLN) or in 3\u2019SLN. SLN enables nanomolar inhibition of the viruses while the hydrophobic linkers confer irreversibility to the inhibition. The combination of these two properties allows for efficacy in vitro against several human or avian influenza strains, as well as against a 2009 pandemic influenza strain ex vivo. Importantly, it is shown that, in mice, one of the compounds provides therapeutic efficacy when administered 24 h post\u2010infection allowing 90% survival as opposed to no survival for the placebo and oseltamivir.\n                  <\/jats:p>","DOI":"10.1002\/advs.202001012","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T06:31:51Z","timestamp":1607927511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Non\u2010Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo"],"prefix":"10.1002","volume":"8","author":[{"given":"Ozgun","family":"Kocabiyik","sequence":"first","affiliation":[{"name":"Insitute of Materials \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cagno","sequence":"additional","affiliation":[{"name":"Insitute of Materials \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"},{"name":"Department of Microbiology and Molecular Medicine University of Geneva  Rue Michel Servet 1 Geneva 1205 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Jacob","family":"Silva","sequence":"additional","affiliation":[{"name":"Insitute of Materials \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Insitute of Materials \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sedano","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Universit\u00e9 Paris\u2010Saclay  Jouy en Josas 78350 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshita","family":"Bhide","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmacy University of Groningen  Groningen 9713GZ The Netherlands"},{"name":"University Medical Center Groningen Department of Medical Microbiology and Infection Prevention (internal postcode EB88) University of Groningen  Hanzeplein 1 Groningen 9713GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Mettier","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Universit\u00e9 Paris\u2010Saclay  Jouy en Josas 78350 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Medaglia","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Medicine University of Geneva  Rue Michel Servet 1 Geneva 1205 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Universit\u00e9 Paris\u2010Saclay  Jouy en Josas 78350 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Constant","sequence":"additional","affiliation":[{"name":"Epithelix Sas  Chemin des Aulx 18 Geneva 1228 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Huang","sequence":"additional","affiliation":[{"name":"Epithelix Sas  Chemin des Aulx 18 Geneva 1228 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Hopital Universitaire de Gen\u00e8ve  Rue Gabrielle Perret Gentil 4 Geneva 1205 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter L. J.","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmacy University of Groningen  Groningen 9713GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Huckriede","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen Department of Medical Microbiology and Infection Prevention (internal postcode EB88) University of Groningen  Hanzeplein 1 Groningen 9713GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Le Goffic","sequence":"additional","affiliation":[{"name":"Virologie et Immunologie Moleculaire Institut National Recherche Agronomique Universit\u00e9 Paris\u2010Saclay  Jouy en Josas 78350 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tapparel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Medicine University of Geneva  Rue Michel Servet 1 Geneva 1205 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-6080","authenticated-orcid":false,"given":"Francesco","family":"Stellacci","sequence":"additional","affiliation":[{"name":"Insitute of Materials \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"},{"name":"Bioengineering Institute Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Station 12 Lausanne 1015 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/507154"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1141"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-3001-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/657314"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-149"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/515616"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/378292"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12254"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.05.057"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122947"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.07.027"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-120611-145115"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2108.141086"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68511-5"},{"key":"e_1_2_6_16_1","unstructured":"Ten threats to global health in 2019 https:\/\/www.who.int\/emergencies\/ten-threats-to-global-health-in-2019(accessed: February 2019)."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0609-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0025-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp421"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01739-09"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03947-14"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2016.1167294"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204839"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14234"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.073"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12446"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3907"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702005"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076363"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01225-13"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc980099n"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.05.028"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201000776"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.5b00917"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.181"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.074"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.034"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.03.018"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6221"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005409"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608803103"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.11.025"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5053"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9318"},{"key":"e_1_2_6_46_1","unstructured":"Primary Screen GlycanScreen primscreen_3818 http:\/\/www.functionalglycomics.org\/glycomics\/HServlet?operation=view&sideMenu=no&psId=primscreen_3818(accessed: February 2019)."},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3346"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0115-z"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.018"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202001012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202001012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202001012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:17:58Z","timestamp":1759789078000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202001012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/advs.202001012"],"URL":"https:\/\/doi.org\/10.1002\/advs.202001012","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.18.996678","asserted-by":"object"}]},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2001012"}}