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Antibiotics are hard and insufficient to treat such hidden internalized bacteria, especially multidrug\u2010resistant (MDR) bacteria. Herein, aggregation\u2010induced emission luminogens (AIEgens) such as\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010diphenyl\u20104\u2010(7\u2010(pyridin\u20104\u2010yl) benzo [\n                    <jats:italic>c<\/jats:italic>\n                    ] [1,2,5] thiadiazol\u20104\u2010yl) aniline functionalized with 1\u2010bromoethane (TBP\u20101) and (3\u2010bromopropyl) trimethylammonium bromide (TBP\u20102) (TBPs) show potent broad\u2010spectrum bactericidal activity against both extracellular and internalized Gram\u2010positive pathogens. TBPs trigger reactive oxygen species (ROS)\u2010mediated membrane damage to kill bacteria, regardless of light irradiation. TBPs effectively kill bacteria without the development of resistance. Additionally, such AIEgens activate mitochondria dependent autophagy to eliminate internalized bacteria in host cells. Compared to the routinely used vancomycin in clinic, TBPs demonstrate comparable efficacy against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) in vivo. The studies suggest that AIEgens are promising new agents for the treatment of MDR bacteria associated infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202001750","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T05:22:17Z","timestamp":1614662537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Efficient Killing of Multidrug\u2010Resistant Internalized Bacteria by AIEgens In Vivo"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-6296","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Center for AIE Research College of Materials Science and Engineering Shenzhen University  Shenzhen 518061 China"},{"name":"National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University  No. 2 Yuanmingyuan West Rd Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University  No. 2 Yuanmingyuan West Rd Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Southern University of Science and Technology  No. 1088 Xueyuan Rd, Nanshan District Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University  No. 2 Yuanmingyuan West Rd Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for AIE Research College of Materials Science and Engineering Shenzhen University  Shenzhen 518061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study Division of Life Science The Hong Kong University of Science and Technology  Clear Water Bay Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-2922","authenticated-orcid":false,"given":"Shang","family":"Chen","sequence":"additional","affiliation":[{"name":"National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University  No. 2 Yuanmingyuan West Rd Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for AIE Research College of Materials Science and Engineering Shenzhen University  Shenzhen 518061 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon H. 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