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Many subtypes of lymphoma, such as Burkitt\u2032s lymphoma and diffuse large B cell lymphoma, are highly aggressive with dismal prognosis even after conventional chemotherapy and radiotherapy. As such, exploring specific biomarkers for lymphoma is of high clinical significance. Herein, a potential marker, CD38, is investigated for differentiating lymphoma. A CD38\u2010targeting monoclonal antibody (mAb, daratumumab) is then radiolabeled with Zr\u201089 and Lu\u2010177 for theranostic applications. As the diagnostic component, the Zr\u201089\u2010labeled mAb is highly specific in delineating CD38\u2010positive lymphoma via positron emission tomography (PET) imaging, while the Lu\u2010177\u2010labeled mAb serves well as the therapeutic component to suppress tumor growth after a one\u2010time administration. These results strongly suggest that CD38 is a lymphoma\u2010specific marker and prove that <jats:sup>89<\/jats:sup>Zr\/<jats:sup>177<\/jats:sup>Lu\u2010labeled daratumumab facilitates immunoPET imaging and radioimmunotherapy of lymphoma in preclinical models. Further clinical evaluation and translation of this CD38\u2010targeted theranostics may be of significant help in lymphoma patient stratification and management.<\/jats:p>","DOI":"10.1002\/advs.202001879","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T05:54:15Z","timestamp":1615787655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["CD38\u2010Targeted Theranostics of Lymphoma with <sup>89<\/sup>Zr\/<sup>177<\/sup>Lu\u2010Labeled Daratumumab"],"prefix":"10.1002","volume":"8","author":[{"given":"Lei","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Peking University First Hospital  Beijing 100034 China"},{"name":"Departments of Radiology and Medical Physics University of Wisconsin \u2013 Madison  Madison WI 53705 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