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Here, a new physiological role of PRMT5 in adipocytes and systemic metabolism is reported. Conditional knockout mice were generated to ablate the\n                    <jats:italic>Prmt5<\/jats:italic>\n                    gene specifically in adipocytes (Prmt5\n                    <jats:sup>AKO<\/jats:sup>\n                    ). The Prmt5\n                    <jats:sup>AKO<\/jats:sup>\n                    mice exhibit sex\u2010 and depot\u2010dependent progressive lipodystrophy that is more pronounced in females and in visceral (than subcutaneous) white fat. The lipodystrophy and associated energy imbalance, hyperlipidemia, hepatic steatosis, glucose intolerance, and insulin resistance are exacerbated by high\u2010fat\u2010diet. Mechanistically, Prmt5 methylates and releases the transcription elongation factor SPT5 from Berardinelli\u2010Seip congenital lipodystrophy 2 (\n                    <jats:italic>Bscl2<\/jats:italic>\n                    , encoding Seipin) promoter, and Prmt5\n                    <jats:sup>AKO<\/jats:sup>\n                    disrupts Seipin\u2010mediated lipid droplet biogenesis. Prmt5 also methylates Sterol Regulatory Element\u2010Binding Transcription Factor 1a (SREBP1a) and promotes lipogenic gene expression, and Prmt5\n                    <jats:sup>AKO<\/jats:sup>\n                    suppresses SREBP1a\u2010dependent fatty acid metabolic pathways in adipocytes. Thus, PRMT5 plays a critical role in regulating lipid metabolism and lipid droplet biogenesis in adipocytes.\n                  <\/jats:p>","DOI":"10.1002\/advs.202002602","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T07:43:13Z","timestamp":1602834193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-2721","authenticated-orcid":false,"given":"Zhihao","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue 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