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However, how BG act in this process is unclear without comprehensive transcriptome landscape of BG. Here, high temporal\u2010resolution investigation of transcriptomes with FACS\u2010sorted BG revealed the dynamic expression of genes within given functions and pathways enabled BG to assist neural migration and construct neuron\u2010glia network. It is found that the peak time of GCs migration (P7\u201010) strikingly coincides with the downregulation of extracellular matrix (ECM) related genes, and the disruption of which by Setdb1 ablation at P7\u201010 in BG leads to significant migration defect of GCs emphasizing the criticality of Nfix\u2010Setdb1 mediated H3K9me3 repressive complex for the precise regulation of GCs migration in vivo. 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