{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:49:38Z","timestamp":1788997778154,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","award":["SKGJ\u2010MED\u2010017"],"award-info":[{"award-number":["SKGJ\u2010MED\u2010017"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In celiac disease (CeD), gluten activates adaptive immune cells that cause damage to the small intestinal mucosa. Histological evaluation of intestinal biopsies allows for grading of disease severity. CeD can effectively be treated with a life\u2010long gluten\u2010free diet. Gluten challenge of treated CeD patients is used to confirm diagnosis and to test drug efficacy in clinical trials, but patients respond with different magnitudes to the same gluten challenge. In this study of 19 well\u2010treated CeD patients, proteome analysis of total tissue or isolated epithelial cell compartment from formalin\u2010fixed paraffin embedded biopsies collected before and after 14\u2010day gluten challenge demonstrates that patients with strong mucosal response to challenge have signs of ongoing tissue inflammation already before challenge. This low\u2010level tissue inflammation at baseline is paralleled by increased gluten specific CD4+ T\u2010cell frequencies in the gut and presence of a low\u2010level blood inflammatory profile. Thus, apparently well\u2010treated CeD is frequently not entirely quiescent, with presence of low\u2010grade inflammation and antigluten immunity in the gut mucosa. Histology assessment alone appears insufficient to judge full recovery and gut mucosal healing of CeD patients. The findings raise a concern whether a seemingly proper gluten\u2010free diet is able to curb gut inflammation in all CeD patients.<\/jats:p>","DOI":"10.1002\/advs.202003526","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T04:51:25Z","timestamp":1609735885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["In Well\u2010Treated Celiac Patients Low\u2010Level Mucosal Inflammation Predicts Response to 14\u2010day Gluten Challenge"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-2112","authenticated-orcid":false,"given":"Jorunn","family":"Stamnaes","sequence":"first","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo  Oslo Norway"},{"name":"Department of Immunology University of Oslo and Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stray","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo  Oslo Norway"},{"name":"Department of Immunology University of Oslo and Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stensland","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Oslo and Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-986X","authenticated-orcid":false,"given":"Vikas K.","family":"Sarna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Oslo University Hospital\u2010Ullev\u00e5l  Oslo 0450 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-5886","authenticated-orcid":false,"given":"Tuula A.","family":"Nyman","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Oslo and Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-5545","authenticated-orcid":false,"given":"Knut E. A.","family":"Lundin","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo  Oslo Norway"},{"name":"Department of Gastroenterology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-704X","authenticated-orcid":false,"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo  Oslo Norway"},{"name":"Department of Immunology University of Oslo and Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.187"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.05.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98819"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619874183"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314461"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.017"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.480"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0257-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24489"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.07.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608610104"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw7756"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1145"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202003526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202003526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202003526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:54:04Z","timestamp":1759755244000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202003526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/advs.202003526"],"URL":"https:\/\/doi.org\/10.1002\/advs.202003526","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"2020-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2003526"}}