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Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three\u2010dimensional (3D), in\u2010situ, and single\u2010particle level remains a fundamental and critical challenge for dry powder inhalation in pre\u2010clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high\u2010precision cross\u2010scale visualization of entire lung anatomy is obtained. Then, co\u2010localized lung\u2010wide datasets of both cyto\u2010architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region\u2010specific distribution and structure\u2010associated deposition of the inhalable particles in lungs, which is undetected by previous methods. 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