{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:41:26Z","timestamp":1788259286865,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1932135"],"award-info":[{"award-number":["U1932135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772875"],"award-info":[{"award-number":["81772875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073889"],"award-info":[{"award-number":["82073889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770961"],"award-info":[{"award-number":["81770961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19JC1415500"],"award-info":[{"award-number":["19JC1415500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1465000"],"award-info":[{"award-number":["20ZR1465000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness, facial defects, and mental disorders, therefore, novel therapeutic modalities are urgently required. Herein, an injectable and stimuli\u2010responsive drug delivery antibacterial hydrogel (CP@Au@DC_AC50) is constructed via a facile grinding method that is inspired by the preparation process of traditional Chinese medicine. The incorporation of gold nanorods can enhance the mechanical strength of the hydrogel and realize photothermal therapy (PTT) and thermosensitive gel\u2010sol transformation to release the gene\u2010targeted drug DC_AC50 on demand in response to low\u2010density near\u2010infrared (NIR) light. The orthotopic model of UM is built successfully and indicates the excellent efficiency of CP@Au@DC_AC50 in killing tumors without damage to normal tissue because of its synergistic mild temperature PTT and gene\u2010targeted therapy. Moreover, the eyeball infection model reveals the remarkable antibacterial properties of the hydrogel which can prevent endophthalmitis in the eyeball. There is negligible difference between the CP@Au@DC_AC50+NIR group and normal group. This NIR light\u2010triggered gene\u2010targeted therapy\/PTT\/antibacterial treatment pattern provides a promising strategy for building multifunctional therapeutic platform against intraocular tumors and exhibits great potential for the clinical treatment of UM.<\/jats:p>","DOI":"10.1002\/advs.202004721","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T04:41:10Z","timestamp":1627706470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["A Novel Stimuli\u2010Responsive Injectable Antibacterial Hydrogel to Achieve Synergetic Photothermal\/Gene\u2010Targeted Therapy towards Uveal Melanoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Shaoyun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200025 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Ouyang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Cixi Center of Biomaterial Surface Engineering Shanghai Institute of Ceramics Chinese Academy of Sciences  Ningbo 315300 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200025 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200025 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200025 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-8143","authenticated-orcid":false,"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"},{"name":"Cixi Center of Biomaterial Surface Engineering Shanghai Institute of Ceramics Chinese Academy of Sciences  Ningbo 315300 P. R. China"},{"name":"School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou 310024 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-7451","authenticated-orcid":false,"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200025 P. R. China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29727"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2019.100557"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197172"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2009.01073.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.040"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.275"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7522-8_15"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.256933"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000146"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202000880"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.03.025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807506106"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b04911"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.045"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.12.080"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.031"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001196"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900046"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00391C"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600292"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15203C"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2017.14"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.07.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2017.0036"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431195"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay9189"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal5240"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.040"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.047"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.038"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2018.2483"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.07.019"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2006.06.001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.112"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3382"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2018.1440400"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2381"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801000"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788803312"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810699"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1088-x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0667"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202004721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202004721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202004721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:40:34Z","timestamp":1759761634000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202004721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":45,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/advs.202004721"],"URL":"https:\/\/doi.org\/10.1002\/advs.202004721","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,31]]},"assertion":[{"value":"2020-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2004721"}}