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However, various challenges related to the dosage form, delivery method, and, especially, application value, hampered the clinical transition of gene therapy. Here, aiming to regulate the cartilage inflammation and degeneration related abnormal IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    mRNA expression in osteoarthritis (OA), the interference oligonucleotides is integrated with the Au nanorods to fabricate the spherical nucleic acids (SNAs), to promote the stability and cell internalization efficiency. Furthermore, the complementary oligonucleotides are grafted onto hyaluronic acid (HA) to obtained DNA\u2010grafted HA (\n                    <jats:sup>DNA<\/jats:sup>\n                    HA) for SNAs delivery by base pairing, resulting in significantly improved injectability and bio\u2010stability of the system. After loading SNAs, the constructed\n                    <jats:sup>DNA<\/jats:sup>\n                    HA\u2010SNAs system (HA\u2010SNAs) performs a reversible NIR\u2010triggered on\u2010demand release of SNAs by photo\u2010thermal induced DNA dehybridization and followed by post\u2010NIR in situ hybridization. The in vitro and in vivo experiments showed that this system down\u2010regulated catabolic proteases and up\u2010regulated anabolic components in cartilage over extended periods of time, to safeguard the chondrocytes against degenerative changes and impede the continual advancement of OA.\n                  <\/jats:p>","DOI":"10.1002\/advs.202004793","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:14:44Z","timestamp":1614597284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["DNA\u2010Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo\u2010Controlled Osteoarthritis Gene Therapy"],"prefix":"10.1002","volume":"8","author":[{"given":"Zhijie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. 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