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A previous study suggested an association between a synonymous SNP (rs1012672, C\u2192T) in\n                    <jats:italic>LRP6<\/jats:italic>\n                    gene and LOAD; and that is indeed correlated with diminished\n                    <jats:italic>LRP6<\/jats:italic>\n                    gene expression in the frontal cortex region. The authors show that LRP6 is a unique Wnt coreceptor on astrocytes, serving as a bimodal switch that modulates their metabolic landscapes. The Wnt\u2010LRP6 mediated mTOR\u2010AKT axis is essential for sustaining glucose metabolism. In its absence, Wnt switches to activate the LRP6\u2010independent Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010PKC\u2010NFAT axis, resulting in a transcription network that favors glutamine and branched chain amino acids (BCAAs) catabolism over glucose metabolism. Exhaustion of these raw materials essential for neurotransmitter biosynthesis and recycling results in compromised synaptic, cognitive, and memory functions; priming for early changes that are frequently found in LOAD. The authors also highlight that intranasal supplementation of glutamine and BCAAs is effective in preserving neuronal integrity and brain functions, proposing a nutrient\u2010based method for delaying cognitive and memory decline when LRP6 cell surface levels and functions are suboptimal.\n                  <\/jats:p>","DOI":"10.1002\/advs.202004993","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T02:28:28Z","timestamp":1624847308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low\u2010Density Lipoprotein Receptor\u2010Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1203-2096","authenticated-orcid":false,"given":"Hei\u2010Man","family":"Chow","sequence":"first","affiliation":[{"name":"School of Life Sciences, Faculty of Science The Chinese University of Hong Kong  999077 Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyne Ka\u2010Li","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science The Chinese University of Hong Kong  999077 Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience Rutgers University  Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth King\u2010Yip","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University  999077 Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara H. 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