{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:16:47Z","timestamp":1792034207767,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The conversion of endogenous H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> into toxic hydroxyl radical (<jats:sup>\u2022<\/jats:sup>OH) via catalytic nanoparticles is explored for tumor therapy and received considerable success. The intrinsic characteristics of microenvironment in tumor cells, such as limited H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and overexpressed glutathione (GSH), hinder the intracellular <jats:sup>\u2022<\/jats:sup>OH accumulation and thus weaken therapeutic efficacy considerably. In this study, fine CaO<jats:sub>2<\/jats:sub> nanoparticles with Cu\u2013ferrocene molecules at the surface (CaO<jats:sub>2<\/jats:sub>\/Cu\u2013ferrocene) are successfully designed and synthesized. Under an acidic condition, the particles release Ca<jats:sup>2+<\/jats:sup> ions and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in a rapid fashion, while they can remain stable in neutral. In addition, agitated production of <jats:sup>\u2022<\/jats:sup>OH occurs following the Fenton reaction of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and ferrocene molecules, and GSH is consumed by Cu<jats:sup>2+<\/jats:sup> ions to avoid the potential <jats:sup>\u2022<\/jats:sup>OH consumption. More interestingly, in addition to the exogenous Ca<jats:sup>2+<\/jats:sup> released by the particles, the enhanced <jats:sup>\u2022<\/jats:sup>OH production facilitates intracellular calcium accumulation by regulating Ca<jats:sup>2+<\/jats:sup> channels and pumps of tumor cells. It turns out that promoted <jats:sup>\u2022<\/jats:sup>OH induction and intracellular calcium overload enable significant in vitro and in vivo antitumor phenomena.<\/jats:p>","DOI":"10.1002\/advs.202100241","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T01:18:26Z","timestamp":1621905506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Cu\u2013Ferrocene\u2010Functionalized CaO<sub>2<\/sub> Nanoparticles to Enable Tumor\u2010Specific Synergistic Therapy with GSH Depletion and Calcium Overload"],"prefix":"10.1002","volume":"8","author":[{"given":"Hanjing","family":"Kong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University  Hangzhou 310027 P. R. 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