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To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D\u2010printed GI radioprotective devices composed of high\u2010Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u00a00.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost\u2010effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202100510","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T17:56:17Z","timestamp":1619546177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection"],"prefix":"10.1002","volume":"8","author":[{"given":"James D.","family":"Byrne","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School  75 Francis St. Boston MA 02115 USA"},{"name":"Harvard Radiation Oncology Program  55 Fruit Street Boston MA 02114 USA"},{"name":"David H. 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