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Sinoporphyrin sodium\u2010mediated sonodynamic therapy (DVDMS\u2010SDT) induces regression of plaque neovascularization in humans without causing obvious side effects. However, a clinical noninvasive theranostic strategy for atherosclerotic plaque neovascularization is urgently needed. A nanoplatform designed for multimodality imaging\u2010guided SDT in plaque angiogenesis theranostics, termed PFP\u2013HMME@PLGA\/MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \u2013ramucirumab nanoparticles (PHPMR NPs), is fabricated. It encapsulates manganese ferrite (MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ), hematoporphyrin monomethyl ether (HMME), and perfluoropentane (PFP) stabilized by polylactic acid\u2010glycolic acid (PLGA) shells and is conjugated to an anti\u2010VEGFR\u20102 antibody. With excellent magnetic resonance imaging (MRI)\/photoacoustic\/ultrasound imaging ability, the distribution of PHPMR NPs in plaque can be observed in real time. Additionally, they actively accumulate in the mitochondria of rabbit aortic endothelial cells (RAECs), and the PHPMR NP\u2010mediated SDT promotes mitochondrial\u2010caspase apoptosis via the production of reactive oxygen species and inhibits the proliferation, migration, and tubulogenesis of RAECs. On day 3, PHPMR NP\u2010mediated SDT induces apoptosis in neovessel endothelial cells and improves hypoxia in the rabbit advanced plaque. On day 28, PHPMR NP\u2010mediated SDT reduces the density of neovessels, subsequently inhibiting intraplaque hemorrhage and inflammation and eventually stabilizing the plaque. Collectively, PHPMR NP\u2010mediated SDT presents a safe and effective theranostic strategy for inhibiting plaque angiogenesis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202100850","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T02:48:49Z","timestamp":1628736529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Low\u2010Intensity Focused Ultrasound\u2010Responsive Ferrite\u2010Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics"],"prefix":"10.1002","volume":"8","author":[{"given":"Jianting","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Chongqing Key Laboratory of Ultrasound Molecular Imaging The Second Affiliated Hospital of Chongqing Medical University  Chongqing 400010 P. R. 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