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SARS\u2010CoV\u20102 infection exhibits similar clinical symptoms and immunopathological sequelae to SARS\u2010CoV infection. Therefore, much of the developmental progress on SARS\u2010CoV vaccines can be utilized for the development of SARS\u2010CoV\u20102 vaccines. Careful antigen selection during development is always of utmost importance for the production of effective vaccines that do not compromise recipient safety. This holds especially true for SARS\u2010CoV vaccines, as several immunopathological disorders are associated with the activity of structural and nonstructural proteins encoded in the virus's genetic material. Whole viral protein and RNA\u2010encoding full\u2010length proteins contain both protective and \u201cdangerous\u201d sequences, unless pathological fragments are deleted. In light of recent advances, peptide vaccines may present a very safe and effective alternative. Peptide vaccines can avoid immunopathological pro\u2010inflammatory sequences, focus immune responses on neutralizing immunogenic epitopes, avoid off\u2010target antigen loss, combine antigens with different protective roles or mechanisms, even from different viral proteins, and avoid mutant escape by employing highly conserved cryptic epitopes. In this review, an attempt is made to exploit the similarities between SARS\u2010CoV and SARS\u2010CoV\u20102 in vaccine antigen screening, with particular attention to the pathological and immunogenic properties of SARS proteins.<\/jats:p>","DOI":"10.1002\/advs.202100985","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T10:43:45Z","timestamp":1624790625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Key Considerations for the Development of Safe and Effective SARS\u2010CoV\u20102 Subunit Vaccine: A Peptide\u2010Based Vaccine Alternative"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-4798","authenticated-orcid":false,"given":"Ahmed O.","family":"Shalash","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed M.","family":"Hussein","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-807X","authenticated-orcid":false,"given":"Mariusz","family":"Skwarczynski","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Toth","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St. Lucia QLD 4072 Australia"},{"name":"Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"},{"name":"School of Pharmacy The University of Queensland  Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.02.034"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.04.018"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization. 2008. 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