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Based on a two\u2010component combination of an\n                    <jats:sc>l<\/jats:sc>\n                    \u2010glutamine amide derivative and benzaldehyde, this gel has very soft rheological properties and self\u2010healing characteristics. It is demonstrated that the gel can be formulated to encapsulate\n                    <jats:sc>l\u2010<\/jats:sc>\n                    DOPA. These drug\u2010loaded gels are characterized, and rapid release of the drug is obtained from the gel network. This drug\u2010loaded hydrogel has appropriate rheological characteristics to be amenable for injection. This system is therefore tested as a vehicle for nasal delivery of neurologically\u2010active drugs\u2014a drug delivery strategy that can potentially avoid first pass liver metabolism and bypass the blood\u2013brain barrier, hence enhancing brain uptake. In vitro tests indicate that the gel has biocompatibility with respect to nasal epithelial cells. Furthermore, animal studies demonstrate that the nasal delivery of a gel loaded with\n                    <jats:sup>3<\/jats:sup>\n                    H\u2010labeled\n                    <jats:sc>l\u2010<\/jats:sc>\n                    DOPA out\u2010performed a simple intranasal\n                    <jats:sc>l\u2010<\/jats:sc>\n                    DOPA solution. This is attributed to longer residence times of the gel in the nasal cavity resulting in increased blood and brain concentrations. It is demonstrated that the likely routes of brain penetration of intranasally\u2010delivered\n                    <jats:sc>l\u2010<\/jats:sc>\n                    DOPA gel involve the trigeminal and olfactory nerves connecting to other brain regions.\n                  <\/jats:p>","DOI":"10.1002\/advs.202101058","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T10:24:50Z","timestamp":1621851890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Enhanced Delivery of Neuroactive Drugs via Nasal Delivery with a Self\u2010Healing Supramolecular Gel"],"prefix":"10.1002","volume":"8","author":[{"given":"Julie Tzu\u2010Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, Faculty of Life Science and Medicine King's College London  150 Stamford street London SE1 9NH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of York  Heslington York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen M. 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