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Despite therapeutic strategies including surgery, chemotherapy, and radiotherapy have been introduced into the war of fighting OS, the 5\u2010year survival rate for patients still remains unchangeable for decades. Besides, the critical bone defects after surgery, drug\u2010resistance and side effects also attenuate the therapeutic effects and predict poor prognosis. Recently, photothermal therapy (PTT) has attracted extensive attention featuring minimal invasiveness and high spatial\u2010temporal precision characteristics. Herein, an ultrathin 2D inorganic ancient pigment Egyptian blue decorated 3D\u2010printing scaffold (CaPCu) with profound PTT efficacy at the second near\u2010infrared (NIR\u2010II) biowindow against OS and enhanced osteogenesis performance is successfully constructed. Importantly, this work uncovers the underlying biological mechanisms that genes associated with cell death, proliferation, and bone development are regulated by CaPCu\u2010scaffold\u2010based therapy. This work not only elucidates the fascinating clinical translation prospects of CaPCu\u2010scaffold\u2010based PTT against OS in NIR\u2010II biowindow, but also demonstrates the potential mechanisms and offers a novel strategy to develop the next\u2010generation, multifunctional tissue\u2010engineering biomaterials.<\/jats:p>","DOI":"10.1002\/advs.202101739","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T07:17:53Z","timestamp":1627888673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Ultrathin 2D Inorganic Ancient Pigment Decorated 3D\u2010Printing Scaffold Enables Photonic Hyperthermia of Osteosarcoma in NIR\u2010II Biowindow and Concurrently Augments Bone Regeneration"],"prefix":"10.1002","volume":"8","author":[{"given":"Chao","family":"He","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic Surgery 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