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Herein, a strategy of dynamic manipulation of trapping force by engineering a dynamic and reversible immunoaffinity microinterface (DynarFace) in a herringbone chip (DynarFace\u2010Chip) for liquid biopsy is proposed. The DynarFace is assembled by magnetically attracting immunomagnetic beads (IMBs) on chip substrate, with merits of convenient operation and reversible assembly. The DynarFace allows accumulating attachment of IMBs on circulating rare cell (CRC) surfaces during hydrodynamically enhanced interface collision, where accumulatively enhanced magnetic trapping force improves capture efficiency toward CRCs with medium expression of biomarkers from blood samples by 134.81% compared with traditional non\u2010dynamic interfaces. Moreover, magnet withdrawing\u2010induced disappearance of trapping force affords DynarFace disassembly and CRC release with high efficiency (&gt;98%) and high viability (\u224898%), compatible with downstream in vitro culture and gene analysis of CRCs. 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