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Propofol is the commonly used anesthetic, but its effects on CTCs and tumor metastasis remain largely unknown. Propofol effects are investigated in an experimental metastasis model by injecting tumor cells and, subsequently, low\u2010 or standard\u2010dose propofol to nude mice through tail vein. Propofol\u2010 or vehicle\u2010treated tumor cells are also injected to the mice. An in vitro tumor cell\u2013vascular endothelial cell adhesion assay, immunofluorescence, and other methods are employed to assess how propofol affects tumor cell adhesion and extension. Propofol induces more lung tumor metastasis in mice than control. Mechanistically, propofol enhances tumor cell adhesion and extension through GABA\n                    <jats:sub>A<\/jats:sub>\n                    R to downregulate TRIM21 expression, leading to upregulation of Src, a protein associated with cell adhesion. These results demonstrate that propofol may promote tumor metastasis through GABA\n                    <jats:sub>A<\/jats:sub>\n                    R\u2013TRIM21\u2013Src mechanism.\n                  <\/jats:p>","DOI":"10.1002\/advs.202102079","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T03:12:38Z","timestamp":1626318758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA\n                    <sub>A<\/sub>\n                    R\u2010Dependent TRIM21 Modulation of Src Expression"],"prefix":"10.1002","volume":"8","author":[{"given":"Qidong","family":"Liu","sequence":"first","affiliation":[{"name":"Anesthesia and Brain Research Institute Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai 200072 P. R. 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