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Herein, a novel porous metal\u2010organic framework (MOF) microneedle (MN) patch enabling photothermal\u2010responsive nitric oxide (NO) delivery for promoting diabetic wound healing is presented. As the NO\u2010loadable copper\u2010benzene\u20101,3,5\u2010tricarboxylate (HKUST\u20101) MOF is encapsulated with graphene oxide (GO), the resultant NO@HKUST\u20101@GO microparticles (NHGs) are imparted with the feature of near\u2010infrared ray (NIR) photothermal response, which facilitate the controlled release of NO molecules. When these NHGs are embedded in a porous PEGDA\u2010MN, the porous structure, larger specific surface area, and sufficient mechanical strength of the integrated MN could promote a more accurate and deeper delivery of NO molecules into the wound site. By applying the resultant NHG\u2010MN to the wound of a type I diabetic rat model, the authors demonstrate that it is capable of accelerating vascularization, tissue regeneration, and collagen deposition, indicating its bright prospect applied in wound healing and other therapeutic scenarios.<\/jats:p>","DOI":"10.1002\/advs.202103449","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T08:25:14Z","timestamp":1637051114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["Porous MOF Microneedle Array Patch with Photothermal Responsive Nitric Oxide Delivery for Wound Healing"],"prefix":"10.1002","volume":"9","author":[{"given":"Shun","family":"Yao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology  Beijing 100850 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