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The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing technologies such as optogenetics and chemogenetics require the introduction of foreign proteins, which adds a layer of complication and hinders their clinical translation. A novel technique, magnetomechanical stimulation (MMS), that enables remote and selective control of astrocytes without genetic modification is described here. MMS exploits the mechanosensitivity of astrocytes and triggers mechanogated Ca<jats:sup>2+<\/jats:sup> and adenosine triphosphate (ATP) signaling by applying a magnetic field to antibody\u2010functionalized magnetic particles that are targeted to astrocytes. Using purpose\u2010built magnetic devices, the mechanosensory threshold of astrocytes is determined, a sub\u2010micrometer particle for effective MMS is identified, the in vivo fate of the particles is established, and cardiovascular responses are induced in rats after particles are delivered to specific brainstem astrocytes. By eliminating the need for device implantation and genetic modification, MMS is a method for controlling astroglial activity with an improved prospect for clinical application than existing technologies.<\/jats:p>","DOI":"10.1002\/advs.202104194","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T01:37:48Z","timestamp":1639964268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-6688","authenticated-orcid":false,"given":"Yichao","family":"Yu","sequence":"first","affiliation":[{"name":"Centre for Advanced Biomedical Imaging Division of Medicine University College London  72 Huntley Street London WC1E 6DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Payne","sequence":"additional","affiliation":[{"name":"Centre for Advanced Biomedical Imaging Division of Medicine University College London  72 Huntley Street London WC1E 6DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nephtali","family":"Marina","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience Research Department of Neuroscience, Physiology and Pharmacology University College London  Gower Street London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Korsak","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience Research Department of Neuroscience, Physiology and Pharmacology University College London  Gower Street London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Southern","sequence":"additional","affiliation":[{"name":"Healthcare Biomagnetics Laboratory University College London  21 Albemarle Street London W1S 4BS UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda\u2010Prieto","sequence":"additional","affiliation":[{"name":"Healthcare Biomagnetics Laboratory University College London  21 Albemarle Street London W1S 4BS UK"},{"name":"Departamento F\u00edsica Aplicada I Universidad del Pa\u00eds Vasco  Bilbao 48013 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel N.","family":"Christie","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Metabolic Neuroscience Research Department of Neuroscience, Physiology and Pharmacology University College London  Gower Street London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Baker","sequence":"additional","affiliation":[{"name":"Centre for Advanced Biomedical Imaging Division of Medicine University College London  72 Huntley Street London WC1E 6DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M. 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