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Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off\u2010target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy with photothermal therapy. After co\u2010assembly engineering optimization, a fibrin\u2010targeting peptide\u2010decorated nanoassembly of DiR (a photothermal probe) and ticagrelor (TGL, an antiplatelet drug) is prepared for thrombus\u2010homing delivery, abbreviated as FT\u2010DT NPs. The elaborately engineered nanoassembly shows multiple advantages, including simple preparation with high drug co\u2010loading capacity, synchronous delivery of two drugs with long systemic circulation, thrombus\u2010targeted accumulation with self\u2010indicating function, as well as photothermal\u2010potentiated thrombus penetration and thrombolysis with high therapeutic efficacy. As expected, FT\u2010DT NPs not only show bright fluorescence signals in the embolized vessels, but also perform photothermal\/antiplatelet synergistic thrombolysis in vivo. This study offers a simple and versatile co\u2010delivery nanoplatform for imaging\u2010guided photothermal\/antiplatelet dual\u2010modality thrombolysis.<\/jats:p>","DOI":"10.1002\/advs.202104264","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T12:08:30Z","timestamp":1637496510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Elaborately Engineering a Self\u2010Indicating Dual\u2010Drug Nanoassembly for Site\u2010Specific Photothermal\u2010Potentiated Thrombus Penetration and Thrombolysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Zhiqiang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang Liaoning 110016 P. R. 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