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Here, COVID\u201019 hyperimmune globulin (COVID\u2010HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP\u2010CorV (Sinopharm COVID\u201019 vaccine). COVID\u2010HIG shows high\u2010affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) spike (S) protein, the receptor\u2010binding domain (RBD), the <jats:italic>N<\/jats:italic>\u2010terminal domain of the S protein, and the nucleocapsid protein; and blocks RBD binding to human angiotensin\u2010converting enzyme 2 (hACE2). Pseudotyped and authentic virus\u2010based assays show that COVID\u2010HIG displays broad\u2010spectrum neutralization effects on a wide variety of SARS\u2010CoV\u20102 variants, including D614G, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Kappa (B.1.617.1), Delta (B.1.617.2), and Omicron (B.1.1.529) in vitro. However, a significant reduction in the neutralization titer is detected against Beta, Delta, and Omicron variants. Additionally, assessments of the prophylactic and treatment efficacy of COVID\u2010HIG in an Adv5\u2010hACE2\u2010transduced IFNAR<jats:sup>\u2212\/\u2212<\/jats:sup> mouse model of SARS\u2010CoV\u20102 infection show significantly reduced weight loss, lung viral loads, and lung pathological injury. Moreover, COVID\u2010HIG exhibits neutralization potency similar to that of anti\u2010SARS\u2010CoV\u20102 hyperimmune globulin from pooled convalescent plasma. Overall, the results demonstrate the potential of COVID\u2010HIG against SARS\u2010CoV\u20102 infection and provide reference for subsequent clinical trials.<\/jats:p>","DOI":"10.1002\/advs.202104333","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T08:14:31Z","timestamp":1649664871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Potent Anti\u2010SARS\u2010CoV\u20102 Efficacy of COVID\u201019 Hyperimmune Globulin from Vaccine\u2010Immunized Plasma"],"prefix":"10.1002","volume":"9","author":[{"given":"Ding","family":"Yu","sequence":"first","affiliation":[{"name":"Chengdu Rongsheng Pharmaceuticals Co. Ltd.  Chengdu 610041 China"},{"name":"Beijing Tiantan Biological Products Co. Ltd.  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