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Catalase, a heme\u2010containing tetramer\u00a0expressed in a broad range of aerobic fungi, shows remarkable efficiency in degrading hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) for fungal survival and host invasion. Here, it is demonstrated that catalase inactivation by\u00a0blue light renders fungal cells highly susceptible to ROS attack. To confirm catalase as a major molecular target of blue light, wild type\u00a0\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    \u00a0are systematically compared with a catalase\u2010deficient mutant strain regarding their susceptibility to ROS through\u00a0410\u00a0nm treatment. Upon testing a wide range of fungal species, it is found that intracellular catalase can be effectively and universally inactivated by 410\u00a0nm blue light. It is also found that\u00a0photoinactivation of catalase in combination with ROS\u2010generating agents is highly effective in total\u00a0eradication of various fungal species, including multiple\u00a0\n                    <jats:italic>Candida auris\u00a0<\/jats:italic>\n                    strains, the causative agent of the global fungal epidemic. In addition, photoinactivation of catalase is shown to facilitate macrophage killing of intracellular\u00a0\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . The antifungal efficacy of catalase photoinactivation is further validated using a\u00a0\n                    <jats:italic>C. albicans\u2010<\/jats:italic>\n                    induced mouse model of skin abrasion. Taken together, the findings offer a novel catalase\u2010photoinactivation approach to address multidrug\u2010resistant\u00a0\n                    <jats:italic>Candida<\/jats:italic>\n                    \u00a0infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202104384","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T05:40:46Z","timestamp":1643953246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Photoinactivation of Catalase Sensitizes\n                    <i>Candida albicans<\/i>\n                    and\n                    <i>Candida auris<\/i>\n                    to ROS\u2010Producing Agents and Immune Cells"],"prefix":"10.1002","volume":"9","author":[{"given":"Pu\u2010Ting","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215 USA"},{"name":"Photonics Center Boston University 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