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It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self\u2010built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar\u2010level, while simultaneously excluding fluorescein (Fl) from the GC5A\u00b7Fl complex in the \u201cswitch\u2010on\u201d mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital\u2010centered to individual\u2010centered testing, visual detection of UA is studied through a smartphone equipped with a color\u2010scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family\u2010centered healthcare style. A high\u2010throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.<\/jats:p>","DOI":"10.1002\/advs.202104463","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:15:55Z","timestamp":1651191355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Noninvasive and Individual\u2010Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing"],"prefix":"10.1002","volume":"9","author":[{"given":"Yaping","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwei","family":"Chai","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion  Tianjin 300193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chao","family":"Geng","sequence":"additional","affiliation":[{"name":"College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento\u2010Organic Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u2010Juan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento\u2010Organic Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Xin","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento\u2010Organic Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-5427","authenticated-orcid":false,"given":"Dong\u2010Sheng","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) State Key Laboratory of Elemento\u2010Organic Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153374"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0222-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0004-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1756"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0115-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22585"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000028"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-122"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.582680"},{"key":"e_1_2_9_10_1","volume":"1","author":"Xiong Q.","year":"2019","journal-title":"Int. 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