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Blood A\u03b2 can become a reliable surrogate biomarker if issues of low concentration for conventional laboratory instruments and uncertain correlation with brain A\u03b2 are solved. Here, brain\u2010to\u2010blood efflux of A\u03b2 is stimulated in AD transgenic mice by orally administrating a chemical that dissociates amyloid plaques and observing the subsequent increase of blood A\u03b2 concentration. 5XFAD transgenic and wild\u2010type mice of varying ages and genders are prepared, and blood samples of each mouse are collected six times for 12 weeks; three weeks of no treatment and additional nine weeks of daily oral administration, ad libitum, of A\u03b2 plaque\u2010dissociating chemical agent. By the dissociation of A\u03b2 aggregates, the altered levels of plasma A\u03b2 distinguish between transgenic and wild\u2010type mice, displaying potential as an amyloid burden marker of AD brains.<\/jats:p>","DOI":"10.1002\/advs.202104542","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T03:33:22Z","timestamp":1643772802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemical\u2010Driven Outflow of Dissociated Amyloid Burden from Brain to Blood"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-9824","authenticated-orcid":false,"given":"Donghee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"},{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin Vincent","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology (KIST) University of Science and Technology (UST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-5652","authenticated-orcid":false,"given":"Hye Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"},{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-7082","authenticated-orcid":false,"given":"YoungSoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"},{"name":"Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"},{"name":"Department of\u00a0Integrative Biotechnology and Translational Medicine Yonsei University  85 Songdogwahak\u2010ro Yeonsu\u2010gu Incheon 21983 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav1388"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00265"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000547"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(09)80099-3"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9020065"},{"key":"e_1_2_9_3_1","first-page":"1","volume":"51","author":"Lee J. 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