{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:39:37Z","timestamp":1789141177688,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22075078"],"award-info":[{"award-number":["22075078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21861162010"],"award-info":[{"award-number":["21861162010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["20XD1421400"],"award-info":[{"award-number":["20XD1421400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JKD01211520"],"award-info":[{"award-number":["JKD01211520"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Potent and selective antifungal agents are urgently needed due to the quick increase of serious invasive fungal infections and the limited antifungal drugs available. Microbial metabolites have been a rich source of antimicrobial agents and have inspired the authors to design and obtain potent and selective antifungal agents, poly(DL\u2010diaminopropionic acid) (PDAP) from the ring\u2010opening polymerization of <jats:italic>\u03b2<\/jats:italic>\u2010amino acid <jats:italic>N<\/jats:italic>\u2010thiocarboxyanhydrides, by mimicking <jats:italic>\u03b5<\/jats:italic>\u2010poly\u2010lysine. PDAP kills fungal cells by penetrating the fungal cytoplasm, generating reactive oxygen, and inducing fungal apoptosis. The optimal PDAP displays potent antifungal activity with minimum inhibitory concentration as low as 0.4\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup> against <jats:italic>Candida albicans<\/jats:italic>, negligible hemolysis and cytotoxicity, and no susceptibility to antifungal resistance. In addition, PDAP effectively inhibits the formation of fungal biofilms and eradicates the mature biofilms. In vivo studies show that PDAP is safe and effective in treating fungal keratitis, which suggests PDAPs as promising new antifungal agents.<\/jats:p>","DOI":"10.1002\/advs.202104871","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:10:21Z","timestamp":1647821421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Microbial Metabolite Inspired <i>\u03b2<\/i>\u2010Peptide Polymers Displaying Potent and Selective Antifungal Activity"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-8550","authenticated-orcid":false,"given":"Donghui","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-7603","authenticated-orcid":false,"given":"Chao","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Cong","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-9249","authenticated-orcid":false,"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Bi","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-9896","authenticated-orcid":false,"given":"Shiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shao","sequence":"additional","affiliation":[{"name":"Shanghai Ruijin Rehabilitation Hospital  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Ruijin Rehabilitation Hospital  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional and Vascular Surgery Shanghai Clinical Research Center for Interventional Medicine Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-086X","authenticated-orcid":false,"given":"Runhui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 200237 China"},{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.11.019"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.46"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00556K"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_2_10_4_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2008.16"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2005.1"},{"key":"e_1_2_10_5_3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609370104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.41.1807"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2004.08.012"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2012.04.001"},{"key":"e_1_2_10_7_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-7677-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113438"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.10.103"},{"key":"e_1_2_10_8_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1260-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201802140"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"e_1_2_10_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1199"},{"key":"e_1_2_10_10_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311150"},{"key":"e_1_2_10_10_5","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c01167"},{"key":"e_1_2_10_10_6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00624"},{"key":"e_1_2_10_10_7","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2915"},{"key":"e_1_2_10_10_8","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01916J"},{"key":"e_1_2_10_10_9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00312"},{"key":"e_1_2_10_10_10","doi-asserted-by":"publisher","DOI":"10.1021\/ja303304j"},{"key":"e_1_2_10_10_11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708254105"},{"key":"e_1_2_10_10_12","doi-asserted-by":"publisher","DOI":"10.1021\/ar900036b"},{"key":"e_1_2_10_10_13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cossms.2013.09.004"},{"key":"e_1_2_10_10_14","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.12.016"},{"key":"e_1_2_10_10_15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805092"},{"key":"e_1_2_10_10_16","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.153"},{"key":"e_1_2_10_10_17","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006772"},{"key":"e_1_2_10_10_18","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104402"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.052"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606129103"},{"key":"e_1_2_10_11_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04462-6"},{"key":"e_1_2_10_11_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00192"},{"key":"e_1_2_10_11_5","doi-asserted-by":"publisher","DOI":"10.1021\/ja064630y"},{"key":"e_1_2_10_11_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104186"},{"key":"e_1_2_10_11_7","author":"Jiang W.","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001697"},{"key":"e_1_2_10_13_1","unstructured":"P. e. a.Wayne CLSI document M27\u2010A3 and Supplement S2008 3."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00202-11"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03301"},{"key":"e_1_2_10_15_1","first-page":"9","author":"Bhattacharya S.","year":"2020","journal-title":"Antibiotics"},{"key":"e_1_2_10_15_2","first-page":"2173","volume":"7","author":"Whaley S. G.","year":"2016","journal-title":"Front. Microbiol."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3767"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7286"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2021.140604"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.11.10"},{"key":"e_1_2_10_18_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.01.003"},{"key":"e_1_2_10_18_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.11.020"},{"key":"e_1_2_10_18_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.031"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2006.11.006"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.01.023"},{"key":"e_1_2_10_19_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.05.013"},{"key":"e_1_2_10_19_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150196"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2020.12.035"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0758-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.3.729"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200701097"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00585-w"},{"key":"e_1_2_10_23_3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3861"},{"key":"e_1_2_10_23_4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.107"},{"key":"e_1_2_10_23_5","first-page":"1","author":"Roudbary M.","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"e_1_2_10_23_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.04.001"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202104871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202104871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202104871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:50:56Z","timestamp":1759791056000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202104871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,20]]},"references-count":69,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/advs.202104871"],"URL":"https:\/\/doi.org\/10.1002\/advs.202104871","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,20]]},"assertion":[{"value":"2022-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2104871"}}