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Herein, the authors designed an inflammation\u2010triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual\u2010targeted synergistic effect on collagen\u2010induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual\u2010target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR\u2010II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system.<\/jats:p>","DOI":"10.1002\/advs.202105188","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T02:47:07Z","timestamp":1642042027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammation\u2010Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging\u2010Guided Therapy of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"9","author":[{"given":"Luoyuan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Key Laboratory of Bioorganic Phosphorous Chemistry &amp; Chemical Biology (Ministry of Education) Tsinghua University  Beijing 100084 P. R. 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