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However, there are still very few effective pharmacological interventions for ROP. Histone deacetylase 6 (HDAC6)\u2010mediated disassembly of photoreceptor cilia has recently been implicated as an early event in the pathogenesis of ROP. Herein it is shown that enhanced expression of HDAC6 by intravitreal injection of adenoviruses encoding HDAC6 induces the typical pathological changes associated with ROP in mice, including disruption of the membranous disks of photoreceptor outer segments and a decrease in electroretinographic amplitudes.\n                    <jats:italic>Hdac6<\/jats:italic>\n                    transgenic mice exhibit similar ROP\u2010related defects in retinal structures and functions and disassembly of photoreceptor cilia, whereas\n                    <jats:italic>Hdac6<\/jats:italic>\n                    knockout mice are resistant to oxygen change\u2010induced retinal defects. It is further shown that blocking HDAC6\u2010mediated cilium disassembly by intravitreal injection of small\u2010molecule compounds protect mice from ROP\u2010associated retinal defects. The findings indicate that pharmacological targeting of the HDAC6\u2010cilium axis may represent a promising strategy for the prevention of ROP.\n                  <\/jats:p>","DOI":"10.1002\/advs.202105365","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T01:24:25Z","timestamp":1653614665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeting the HDAC6\u2010Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-7126","authenticated-orcid":false,"given":"Jie","family":"Ran","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences Shandong Provincial Key Laboratory of Animal Resistance Biology Collaborative Innovation Center of Cell Biology in Universities of Shandong College of Life Sciences Shandong Normal University  Jinan 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