{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:04:19Z","timestamp":1792605859761,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62175031"],"award-info":[{"award-number":["62175031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61875141"],"award-info":[{"award-number":["61875141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC) commonly emerges in an immunologically \u201ccold\u201d state, thereafter protects it away from cytolytic attack by tumor\u2010infiltrating lymphocytes, resulting in poor response to immunotherapy. Herein, an acidic\/photo\u2010sensitive dendritic cell (DCs)\u2010based neoantigen nano\u2010vaccine has been explored to convert tumor immune \u201ccold\u201d state into \u201chot\u201d, and remodel tumor\u2010associated neutrophils to potentiate anticancer immune response for enhancing immunotherapy efficiency. The nano\u2010vaccine is constructed by SiPCCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010hybridized mesoporous silica with coordination of Fe(III)\u2010captopril, and coating with exfoliated membrane of matured DCs by H22\u2010specific neoantigen stimulation. The nano\u2010vaccines actively target H22 tumors and induce immunological cell death to boost tumor\u2010associated antigen release by the generation of excess\n                    <jats:italic>\n                      <jats:sup>1<\/jats:sup>\n                    <\/jats:italic>\n                    O\n                    <jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:italic>\n                    through photodynamic therapy, which act as in situ tumor vaccination to strengthen antitumor T\u2010cell response against primary H22 tumor growth. Interestingly, the nano\u2010vaccines are also home to lymph nodes to directly induce the activation and proliferation of neoantigen\u2010specific T cells to suppress the primary\/distal tumor growth. Moreover, the acidic\u2010triggered captopril release in tumor microenvironment can polarize the protumoral N2 phenotype neutrophils to antitumor N1 phenotype for improving the immune effects to achieve complete tumor regression (83%) in H22\u2010bearing mice and prolong the survival time. This work provides an alternative approach for developing novel HCC immunotherapy strategies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202105631","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:16:27Z","timestamp":1644477387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Remodeling Tumor\u2010Associated Neutrophils to Enhance Dendritic Cell\u2010Based HCC Neoantigen Nano\u2010Vaccine Efficiency"],"prefix":"10.1002","volume":"9","author":[{"given":"Yunhao","family":"Wang","sequence":"first","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfu","family":"Zhao","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youshi","family":"Zheng","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishun","family":"Liao","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Cai","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Zhang","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Zeng","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Liver Disease Center The First Affiliated Hospital of Fujian Medical University  Fuzhou 350005 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-4981","authenticated-orcid":false,"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[{"name":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou 350025 P. R. China"},{"name":"Mengchao Med\u2010X Center Fuzhou University  Fuzhou 350116 P. R. China"},{"name":"CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.122"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy510"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0073-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00395-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30937-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03555"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i8.1020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10673"},{"key":"e_1_2_8_11_1","first-page":"504","author":"Gravitz L.","year":"2013","journal-title":"Nature"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00346-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0792-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22991"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000217"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00448-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01467-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.130"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0648-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1796-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.041"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1067744"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31808"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006484"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100241"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03833"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001808"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703969"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-020-00429-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101195"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c00818"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03788"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_8_34_1","volume":"9","author":"Alzeibak R.","year":"2021","journal-title":"Int. J. Cancer"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05223-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21820"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.07.065"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c09657"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700648"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC02408A"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003504"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101341"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00532"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4910"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202105631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202105631","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202105631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:16:41Z","timestamp":1759774601000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202105631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/advs.202105631"],"URL":"https:\/\/doi.org\/10.1002\/advs.202105631","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"assertion":[{"value":"2021-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2105631"}}