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Early and accurate virus diagnosis is critical to prevent the spread of the virus, especially when no specific vaccine or effective medicine is available. In clinics, the most commonly used viral detection methods are molecular techniques that involve the measurement of nucleic acids or proteins biomarkers. However, most clinic\u2010based methods require complex infrastructure and expensive equipment, which are not suitable for low\u2010resource settings. Over the past years, smartphone\u2010based point\u2010of\u2010care testing (POCT) has rapidly emerged as a potential alternative to laboratory\u2010based clinical diagnosis. This review summarizes the latest development of virus detection. First, laboratory\u2010based and POCT\u2010based viral diagnostic techniques are compared, both of which rely on immunosensing and nucleic acid detection. Then, various smartphone\u2010based POCT diagnostic techniques, including optical biosensors, electrochemical biosensors, and other types of biosensors are discussed. Moreover, this review covers the development of smartphone\u2010based POCT diagnostics for various viruses including COVID\u201019, Ebola, influenza, Zika, HIV, et\u00a0al. Finally, the prospects and challenges of smartphone\u2010based POCT diagnostics are discussed. It is believed that this review will aid researchers better understand the current challenges and prospects for achieving the ultimate goal of containing disease\u2010causing viruses worldwide.<\/jats:p>","DOI":"10.1002\/advs.202105904","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T01:32:06Z","timestamp":1649381526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":208,"title":["Virus Detection: From State\u2010of\u2010the\u2010Art Laboratories to Smartphone\u2010Based Point\u2010of\u2010Care Testing"],"prefix":"10.1002","volume":"9","author":[{"given":"Meng","family":"Xiao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen 518107 P. R. 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