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However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA\u2010needles) with a screw\u2010thread structure at the tip (ST\u2010needle) and the hydrogel with the function of adhesive metal and loaded drug sustained\u2010release structure are designed, through the minimally invasive and precise positioning of lesions by ST\u2010needles, the dry\u2010wet conversion of hydrogel with absorbing fluids and swelling, and the rotation back of ST\u2010needles, the hydrogel is precisely positioned in the subchondral bone with physical barrier to achieve precise positioning therapy for lesions. In vitro experiments show that the ST\u2010needle penetrates the physical barrier of cartilage and enters the subchondral bone. Simultaneously, the hydrogel transfer efficiency of the ST\u2010needle (73.25%) is significantly higher than that of the CA\u2010needle (29.92%) due to the protective effect of the screw\u2010thread structure. In vivo experiments demonstrate that precise positioning in subchondral bone in osteoarthritis rats with ST\u2010needles effectively inhibits abnormal subchondral bone remodeling, alleviating the degeneration and degradation of cartilage. Therefore, ST\u2010needles achieve lesion positioning therapy through minimally invasive penetration of physical barriers, precisely positioning within lesions, and delivering hydrogel to release drugs.<\/jats:p>","DOI":"10.1002\/advs.202200079","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T09:45:10Z","timestamp":1649670310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-9032","authenticated-orcid":false,"given":"Feng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. 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