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It is found that overexpression of farnesoid X receptor (FXR), a main receptor for bile acids, improves the retention and cardioprotection of adipose tissue\u2010derived MSC (ADSC) administered by intramyocardial injection in mice with myocardial infarction (MI), which shows enhanced antiapoptotic, proangiogenic, and antifibrotic effects. RNA sequencing, LC\u2010MS\/MS, and loss\u2010of\u2010function studies reveal that FXR overexpression promotes ADSC paracrine angiogenesis via Angptl4. FXR overexpression improves ADSC survival in vivo but fails in vitro. By performing bile acid\u2010targeted metabolomics using ischemic heart tissue, 19 bile acids are identified. Among them, cholic acid and deoxycholic acid significantly increase Angptl4 secretion from ADSC overexpressing FXR and further improve their proangiogenic capability. Moreover, ADSC overexpressing FXR shows significantly lower apoptosis by upregulating Nqo\u20101 expression only in the presence of FXR ligands. Retinoid X receptor\n                    <jats:italic>\u03b1<\/jats:italic>\n                    is identified as a coactivator of FXR. It is first demonstrated that there is a bile acid pool in the myocardial microenvironment. Targeting the bile acid\u2010FXR axis may be a novel strategy for improving the curative effect of MSC\u2010based therapy for MI.\n                  <\/jats:p>","DOI":"10.1002\/advs.202200431","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T09:11:50Z","timestamp":1656839510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids"],"prefix":"10.1002","volume":"9","author":[{"given":"Yunlong","family":"Xia","sequence":"first","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Periodontology School of Stomatology Fourth Military Medical University  Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"},{"name":"Cardiology General Hospital of Eastern Theater Command of Chinese PLA  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Fan","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qi","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congye","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Peng","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Xijing Hospital Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxu","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Toxicology Shanxi Provincial Key Lab of Free Radical Biology and Medicine Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Fourth Military Medical University  Xi'an Shaanxi 710032 P. 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