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Inflammation is one core cause of the DED vicious cycle, a multifactorial deterioration in DED process. However, there are also reactive oxygen species (ROS) regulating inflammation and other points in the cycle from the upstream, leading to treatment failure of current therapies merely targeting inflammation. Accordingly, the authors develop micelle\u2010based eye drops (more specifically p38 mitogen\u2010activated protein kinases (MAPK) inhibitor Losmapimod (Los)\u2010loaded and ROS scavenger Tempo (Tem)\u2010conjugated cationic polypeptide micelles, designated as MTem\/Los) for safe and efficient DED management. Cationic MTem\/Los improve ocular retention of conjugated water\u2010soluble Tem and loaded water\u2010insoluble Los via electrostatic interaction with negatively charged mucin on the cornea, enabling an increase in therapeutic efficiency and a decrease in dosing frequency. Mechanistically, MTem\/Los effectively decrease ROS over\u2010production, reduce the expression of proinflammatory cytokines and chemokines, restrain macrophage proinflammatory phenotypic transformation, and inhibit cell apoptosis. Therapeutically, the dual\u2010functional MTem\/Los suppress the inflammatory response, reverse corneal epithelial defect, save goblet cell dysfunction, and recover tear secretion, thus breaking the vicious cycle and alleviating the DED. Moreover, MTem\/Los exhibit excellent biocompatibility and tolerability for potential application as a simple and rapid treatment of oxidative stress\u2010 and inflammation\u2010induced disorders, including DED.<\/jats:p>","DOI":"10.1002\/advs.202200435","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T08:06:14Z","timestamp":1650269174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Anti\u2010Oxidative and Anti\u2010Inflammatory Micelles: Break the Dry Eye Vicious Cycle"],"prefix":"10.1002","volume":"9","author":[{"given":"Su","family":"Li","sequence":"first","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang University  88 Jiefang Road Hangzhou 310009 P. R. 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