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Herein, titanium sulfide nanosheets (TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs) are prepared as cascade bioreactors for sequential gas\u2013sonodynamic cancer therapy. TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs themselves as hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donors can burst release H\n                    <jats:sub>2<\/jats:sub>\n                    S gas. Following H\n                    <jats:sub>2<\/jats:sub>\n                    S generation, TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs are gradually degraded to become S\u2010defective and partly oxidized into TiO\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    on their surface, which endows TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs with high sonodynamic properties under ultrasound (US) irradiation. In vitro and in vivo experiments show the excellent therapeutic effects of TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs. In detail, large amounts of H\n                    <jats:sub>2<\/jats:sub>\n                    S gas and reactive oxygen species (ROS) can simultaneously inhibit mitochondrial respiration and ATP synthesis, leading to cancer cell apoptosis. Of note, H\n                    <jats:sub>2<\/jats:sub>\n                    S gas also plays important roles in modulating and activating the immune system to effectively inhibit pulmonary metastasis. Finally, the metabolizable TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs are excreted out of the body without inducing any significant long\u2010term toxicity. Collectively, this\u00a0work establishes a cascade bioreactor of TiS\n                    <jats:italic>\n                      <jats:sub>X<\/jats:sub>\n                    <\/jats:italic>\n                    NSs with satisfactory H\n                    <jats:sub>2<\/jats:sub>\n                    S release ability and excellent ROS generation properties under US irradiation for programmed gas\u2013sonodynamic cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202201069","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T14:41:56Z","timestamp":1661524916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Titanium Sulfide Nanosheets Serve as Cascade Bioreactors for H\n                    <sub>2<\/sub>\n                    S\u2010Mediated Programmed Gas\u2013Sonodynamic Cancer Therapy"],"prefix":"10.1002","volume":"9","author":[{"given":"Guangqiang","family":"Li","sequence":"first","affiliation":[{"name":"College of Biomedicine and Health College of Life Science and Technology Huazhong Agricultural University  Wuhan 430070 China"},{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials &amp; Devices Soochow University  Suzhou 215123 China"},{"name":"Brain Research Institute Research Center of Neurological Diseases Taihe Hospital Hubei University of Medicine  Shiyan Hubei 442000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials &amp; Devices Soochow University  Suzhou 215123 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