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In this work, an interventional sonothrombolysis (IST) method is developed to realize the thrombolysis on LVAD. A pair of ultrasound transducer rings is installed on the shell of LVAD, and drug\u2010loaded microbubbles are injected into the LVAD through the interventional method. The microbubbles are adhere on the thrombus with the coated thrombus\u2010targeted drugs, and the thrombolytic drugs carried by the bubbles are brought into the thrombus by the cavitation of bubbles under the ultrasound. In a proof\u2010of\u2010concept experiment in a live sheep model, the thrombus on LVAD is dissolved in 30\u00a0min, without damages on LVADs and organs. This IST exhibits to be more efficient and safer compared with other thrombolysis methods on LVAD.<\/jats:p>","DOI":"10.1002\/advs.202201291","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T04:36:23Z","timestamp":1653539783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-307X","authenticated-orcid":false,"given":"Xiaobing","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuilin","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Zhou","sequence":"additional","affiliation":[{"name":"Animal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences  Beijing 100037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Animal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences  Beijing 100037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchun","family":"Cui","sequence":"additional","affiliation":[{"name":"Animal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences  Beijing 100037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-0989","authenticated-orcid":false,"given":"Haosheng","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.058412"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa180"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.573"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2020.10.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz8204"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03492-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-020-00228-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf9033"},{"key":"e_1_2_10_10_1","unstructured":"IEC 61157\u20132007 International Electrotechnical Commission Geneva Switzerland2007."},{"key":"e_1_2_10_11_1","author":"Stride E.","year":"2019","journal-title":"Nat. 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