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Here, inspired by the unique suction\u2010cup structures of abalones, a novel adhesive and photo\u2010responsive microparticle (MP) delivery system is developed to treat periodontitis through microfluidic electrospray technology. Such MPs are generated by quickly ionic cross\u2010linking of sodium alginate together with photo\u2010curing of poly(ethylene glycol) diacrylate of the distorted microfluidic droplets during their high\u2010speed dropping into calcium chloride solution. Attributing to their unique concave structures, the abalone\u2010inspired MPs exhibit desired underwater adhesion ability and stability under running water. In addition, due to the loading of antibiotics minocycline hydrochloride and near\u2010infrared (NIR)\u2010responsive black phosphorus during their fabrication, the resultant MPs can not only eradicate bacteria directly, but also realize a controllable and effective drug release upon NIR irradiation. Based on these features, it is demonstrated from in vivo periodontitis that the abalone\u2010inspired MPs are firmly adhesive and can controlled\u2010release drugs on the tooth, and thus have outstanding antibacterial efficacy against <jats:italic>Porphyromonas gingivalis<\/jats:italic>. These results indicate the particular values of the abalone\u2010inspired MPs for oral\u2010related disease treatment.<\/jats:p>","DOI":"10.1002\/advs.202202829","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T15:18:32Z","timestamp":1661872712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Abalone\u2010Inspired Adhesive and Photo\u2010Responsive Microparticle Delivery Systems for Periodontal Drug Therapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-7868","authenticated-orcid":false,"given":"Chuanhui","family":"Song","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210002 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